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Glimipiride 3mg Metformin HCL 1000mg

Glimipiride 3mg Metformin HCL 1000mg
Glimipiride 3mg Metformin HCL 1000mg
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Product Code : 294
Brand Name : Glimith MF-3 1000 SR
Product Description

Glimipiride 3mg Metformin HCL 1000mg

Clinical Pharmacology Glimith Mf-3 1000 Sr Contains Two Oral Anti-hyperglycemic Drugs Glimepiride And Metformin Hydrochloride Used In The Management Of Type-2 Diabetes (niddm). Pharmacodynamics Glimepiride: The Primary Mechanism Of Action Of Glimepiride In Lowering Blood Glucose Appears To Be Dependent On Stimulating The Release Of Insulin From Functioning Pancreatic Beta Cells. In Addition, Extra-pancreatic Effects May Also Play A Role In The Activity Of Sulphonylureas Such As Glimepiride. Metformin: Metformin Improves Glucose Tolerance In Patients With Type-2 Diabetes (niddm), Lowering Both Basal And Postprandial Plasma Glucose. Metformin Decreases Hepatic Glucose Production, Decreases Intestinal Absorption Of Glucose, And Improves Insulin Sensitivity By Increasing Peripheral Glucose Uptake And Utilization. Hence, The Combination Of Glimepiride And Metformin Sustained-release Complements Each Other And Provides Better Glycemic Control In Management Of Type-2 Diabetes And Probably In The Prevention Of Its Associated Macrovascular And Microvascular Complications. Pharmacokinetics Absorption Glimepiride: After Oral Administration, Glimepiride Is Completely Absorbed From The Gi Tract. Studies Have Shown Significant Absorption Of Glimepiride Within 1 Hour After Administration And Peak Drug Levels (cmax) At 2 To 3 Hours. When Glimepiride Was Given With Meals, The Mean Tmax (time To Reach Cmax) Was Slightly Increased (12%) And The Mean Cmax And Auc (area Under The Curve) Were Slightly Decreased (8% And 9%, Respectively). Metformin Sustained-release: The Absolute Bioavailability Of A Metformin 500-mg Tablet Given Under Fasting Conditions Is Approximately 50-60%. Following A Single Oral Dose Of Metformin Sustained-release, Cmax Is Achieved Within 4-8 Hours. Peak Plasma Levels Are Approximately 20% Lower Compared To The Same Dose Of Metformin Immediate Release, However, The Extent Of Absorption (as Measured By Auc) Is Similar To Immediate Release. Both High And Low Fat Meals Had The Same Effect On The Pharmacokinetics Of Sustained Release. Indications Glimith Mf-3 1000 Sr Is Indicated As An Adjunct To Diet And Exercise To Improve Glycemic Control In Patients With Type-2 Diabetes Who Are Already Treated With A Combination Of Glimepiride And Metformin Or Whose Diabetes Is Not Adequately Controlled With Metformin Alone, Or For Those Patients Who Have Initially Responded To Glimepiride Alone And Require Additional Glycemic Control. Dosage & Administration General Dosage Should Be Individualized On The Basis Of Both Effectiveness And Tolerance. The Combination Should Be Given Once Daily With Meals And Should Be Started At A 3 Low Dose. The Initial Recommended Dose Is One Tablet Once Daily With Breakfast Or First Main Meal Of The Day.


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